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Each breed is descended from a limited number of dogs. Because breeders have sought to create animals that have certain fixed attributes, many purebred dogs today are inbred. Genetically this means that, while all purebreds do not have significant health problems, they are predisposed to a range of hereditary and congenital diseases, including skin and eye conditions, allergies, various cancers, cardiac problems, and abnormalities in the kidneys and other organs.